| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 200802 | 25 ug | $80 |
| Clone | m198AR2b |
|---|---|
| Application | FC |
| Reactivity | Mouse |
| Format | Biotin |
| Target Name | CD198, CCR8 CC-CKR-8, Ter1 |
| Isotype | Rat IgG2b |
| Antibody Type | Monoclonal |
| Regulatory Status | RUO |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA |
| Protein Concentration | 0.2 mg/mL |
| Storage&Handling | The antibody solution should be stored between 2°C and 8°C |
| Recommended Usage | For flow cytometric staining, it is recommended to use less than 0.5 ug of this reagent per 0.5-1.0 million cells in a 100 µL volume. Optimal reagent performance should be determined by titration for each specific application. |
CCR8 is a 41 kDa seven-transmembrane GPCR in the β-chemokine receptor family, expressed on thymocytes, Tregs, NKT, Th2 cells, NK cells, monocytes, macrophages, and some dendritic cells, with highest levels in the thymus and tumor-infiltrating Tregs. It binds CCL1 (I-309), CCL17 (TARC), and CCL4 (MIP-1β) to mediate chemotaxis, thymocyte apoptosis, and positioning of activated T cells in immune sites. CCR8’s selective enrichment on tumor Tregs makes it a potential target for cancer immunotherapy.
Biotin Anti-Mouse CCR8 (CD198) TDS
