| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 200901 | 100 ug | $40 | ||
| 200902 | 500 ug | $70 |
| Clone | RA3-6B2 |
|---|---|
| Application | FC |
| Reactivity | Human, Mouse |
| Format | Purified |
| Target Name | CD45R, B220 |
| Isotype | Rat IgG2a |
| Antibody Type | Monoclonal |
| Regulatory Status | RUO |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide |
| Protein Concentration | 0.5 mg/mL |
| Storage and Handling | The antibody solution should be stored between 2°C and 8°C |
CD45R, also known as B220, is an isoform of CD45 (PTPRC), a member of the protein tyrosine phosphatase (PTP) family. With a molecular weight of approximately 180–240 kDa, CD45R is a transmembrane glycoprotein expressed on B cells at all developmental stages, as well as on activated B cells, subsets of T and NK cells, and certain abnormal T cell populations involved in systemic autoimmunity in MRL-Faslpr and MRL-Fasgld mice. Structurally, CD45R consists of an extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains. Functionally, CD45R plays a critical role in T cell receptor (TCR) and B cell receptor (BCR) signaling by regulating Src-family kinases, which are essential for lymphocyte activation and development. The primary ligands for CD45 include galectin-1, CD2, CD3, and CD4. CD45R is widely used as a pan-B cell marker, though CD19 may provide greater specificity for B cells.
Anti-Mouse/human CD45R/B220 TDS
