The antibody solution should be stored between 2°C and 8°C
Recommended Usage
For flow cytometric staining, it is recommended to use less than 0.25 ug of this reagent per 0.5-1.0 million cells in a 100 µL volume. Optimal reagent performance should be determined by titration for each specific application.
Background Information
CD19, also known as B-lymphocyte antigen CD19, B4, Leu-12, or CVID3, is a type I transmembrane glycoprotein encoded by the CD19 gene. It is expressed throughout B cell development from the pro-B stage to mature B cells and is present on most B lineage cells. CD19 functions as an adaptor protein, recruiting cytoplasmic signaling molecules to the membrane, and forms part of the CD19/CD21/CD81 complex, which lowers the activation threshold for B cell receptor (BCR) signaling. Because of its consistent expression on B cells, CD19 serves as a key biomarker for B cell development and is widely used in the diagnosis of B cell lymphomas and leukemias. It is also a major therapeutic target in immunotherapies, including CAR T-cell therapy for B cell malignancies.
