Recombinant Human Trop2 (Gln24-Thr274) with C-terminus His-Avi tag is expressed in CHO cell and conjugated to APC.
accession number
P09758
Molecular Weight
The protein has a predicted molecular weight of 29 kDa. Under DTT-reducing conditions, it migrates at approximately 40-50 kDa on SDS-PAGE prior to conjugation.
Affinity Tag
C-His
Formulation
1xPBS buffer, pH7.4, 0.09% NaN3 with a carrier protein
Endotoxin level
Not tested
Protein Concentration
25µg size is bottled at 0.1mg/mL concentration. 100 µg size is bottled at lot specific concentration.
Storage and Handling
Briefly centrifuge the vial upon receipt. An unopened vial may be stored at 2–8°C for up to six months.
Background Information
TROP-2, also known as TACSTD2, is a 35.7 kD protein that belongs to the EpCAM family. It is a cell surface receptor that can transduce calcium signals. Mutations of this gene are associated with gelatinous drop-like corneal dystrophy. TROP-2 is highly expressed in a variety of epithelial cancers, making it a potential therapeutic target. The cytoplasmic tail of TROP-2 contains potential phosphorylation sites and a phosphatidyl-inositol binding sequence, suggesting its role in signal transduction. As a member of a family of at least two type I membrane proteins, TROP-2 is closely related to EpCAM, also known as TROP-1, and may play a role in regulating carcinoma cell growth.
