| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 801505 | 25 ug | $245 | ||
| 801506 | 100 ug | $595 |
| Application | FC |
|---|---|
| Format | Liquid, APC |
| Expression Host | HEK293 |
| Target Name | Mesothelin, MPF, MSLN |
| Species | Human |
| Sources | Human Mesothelin protein (Accession # AAH09272.1) (Glu296-Gly580) with C-terminus His tag is expressed in HEK293 cells and conjugated to APC. |
| Accession Number | Q13421 |
| Molecular Weight | The protein has a predicted molecular weight of 34kDa. Under DTT-reducing conditions, it migrates at approximately 35-45 kDa on SDS-PAGE prior to conjugation. |
| Affinity Tag | C-His |
| Regulatory Status | RUO |
| Formulation | 1xPBS buffer, pH7.4, 0.09% NaN3 with a carrier protein |
| Endotoxin level | Not tested |
| Protein Concentration | 25µg size is bottled at 0.1mg/mL concentration. 100 µg size is bottled at lot specific concentration. |
| Storage and Handling | Briefly centrifuge the vial upon receipt. An unopened vial may be stored at 2–8°C for up to six months. |
Mesothelin (MSLN), also known as CAK1, is a 70 kDa cell-surface protein cleaved into MPF (30 kDa) and mesothelin (40 kDa). MPF acts as a cytokine, while mesothelin is membrane-bound via glycosylphosphatidylinositol. It is overexpressed in various cancers, including mesotheliomas and ovarian cancer, and interacts with MUC16/CA-125, a cancer biomarker. Elevated mesothelin levels in serum make it a target for diagnostics and therapies, such as the recombinant immunotoxin SS1P, which has shown promise in clinical trials.
APC Conjugated Human Mesothelin (E296-G580) Protein (C-His) TDS
