Andes Virus Glycoprotein Gc (H953F) (C-His)

Cat #	Size	Price	Quantity
607001	25 μg	$300
607002	100 μg	$798

Bulk/Custom

Product Details

Application	ELISA, BLI
Format	Liquid, Purified
Expression Host	CHO
Target Name	Andes virus glycoprotein Gc, Andes virus Gc protein, ANDV Gc glycoprotein, Andes orthohantavirus glycoprotein Gc, Hantavirus envelope glycoprotein Gc, G2 glycoprotein
Species	Andes Virus
accession number	AF291703.2
Sources	Recombinant Andes Virus Glycoprotein Gc (Glu652-Asn1107) (H953F) with a C-terminal histidine tag is expressed in CHO cells. The protein is derived from the Andes virus strain Chile-9717869.
Molecular Weight	This protein has a predicted molecular weight of 50–52 kDa (without glycosylation).
Affinity Tag	C-His
Purity	>95% based on SDS-PAGE under reducing condition
Regulatory Status	RUO
Formulation	1xPBS buffer, pH7.4, 0.22 µm filtered
Endotoxin level	Not tested
Protein Concentration	25µg size is bottled at 0.2mg/mL concentration. 100 µg size is supplied at a lot-specific concentration.
Storage and Handling	Briefly centrifuge the vial upon receipt. An unopened vial can be stored at 4°C for up to 2 weeks, or at -20°C or below for up to six months. The protein may be further diluted to 0.1 mg/mL using 0.22 µm-filtered PBS buffer (pH 7.4). For long-term storage, the diluted stock solution should be aliquoted and stored at ≤ –70°C to minimize freeze-thaw cycles. If additional dilution is required, carrier proteins such as FBS or BSA should be added to maintain protein stability.

Background Information

Andes virus (ANDV) is a member of the genus Orthohantavirus in the family Hantaviridae and is a major etiological agent of hantavirus cardiopulmonary syndrome (HCPS) in South America. Unlike most hantaviruses, Andes virus has demonstrated the ability for person-to-person transmission, making it a significant emerging infectious disease threat.
The Andes virus glycoprotein precursor (GPC) is proteolytically cleaved into the envelope glycoproteins Gn and Gc. The Gc glycoprotein is a class II viral fusion protein responsible for mediating fusion between the viral envelope and host-cell membrane during viral entry. Gc also serves as an important target for neutralizing antibodies and antiviral therapeutics. Recombinant Andes Virus Glycoprotein Gc is widely used in studies of viral entry, membrane fusion, structural biology, epitope mapping, serological assay development, and antibody discovery.

Learn more about Andes Virus in our detailed Infographic.

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