| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 111501 | 25 ug | $80 | ||
| 111502 | 100 ug | $170 |
| Clone | TBX21M1 |
|---|---|
| Application | Flow Cytometry |
| Reactivity | Human, Mouse |
| Format | Purified |
| Target Name | T-bet, T box 21, T-box expressed in T cells |
| Isotype | Mouse IgG1 |
| Antibody Type | Monoclonal |
| Regulatory Status | RUO |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide |
| Protein Concentration | 0.5 mg/mL |
| Storage&Handling | The antibody solution should be stored between 2°C and 8°C |
| See All Formats | Clone TBX21M1 |
T-bet (TBX21) is a T-box transcription factor that plays a central role in the differentiation and function of Th1 CD4⁺ T cells in both humans and mice. Its expression is induced by IFN-γ and it directly regulates the transcription of IFN-γ, IL-12 receptor β, and IL-2 through modulation of chromatin accessibility. Loss of T-bet impairs Th1 lineage commitment, while ectopic expression promotes Th1 polarization. Beyond T cells, T-bet also contributes to B cell class-switch recombination. Due to its conserved function across species, T-bet is a key regulator of cell-mediated immunity and inflammatory responses.
Mouse IgG1 Isotype Control Antibody
Anti-human/mouse T-bet Antibody TDS
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