| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 203201 | 100 ug | $70 | ||
| 203202 | 500 ug | $150 |
| Clone | 53-7.3 |
|---|---|
| Application | Flow Cytometry |
| Reactivity | Mouse |
| Format | Purified |
| Target Name | CD5, Ly-12, Ly-1, Lyt-1, Tp67 |
| Isotype | Rat IgG2a |
| Antibody Type | Monoclonal |
| Regulatory Status | RUO |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide |
| Protein Concentration | 0.5 mg/mL |
| Storage&Handling | The antibody solution should be stored between 2°C and 8°C |
| See All Formats | Clone 53-7.3 |
CD5 is a single-chain transmembrane glycoprotein expressed predominantly on mouse T cells and B1 cells, a specialized subset of IgM-secreting B cells. It functions as a negative regulator of antigen receptor signaling by attenuating signals from the T cell receptor (TCR) and B cell receptor (BCR), thereby modulating lymphocyte activation thresholds. Through interactions with intracellular phosphatases such as SHP-1, CD5 helps maintain immune tolerance and limits autoreactive responses. CD5-expressing cells are also associated with regulatory functions, including cytokine production such as IL-10. Owing to its regulatory role, CD5 is an important marker and functional modulator in mouse T and B cell development, activation, and immune homeostasis.
Rat IgG2a Isotype Control Antibody
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