Andes Virus Gn Base Protein (C-His)

Cat #	Size	Price	Quantity
607301	25 μg	$200
607302	100 μg	$550

Bulk/Custom

Product Details

Application	ELISA, BLI
Format	Liquid, Purified
Expression Host	CHO
Target Name	Andes virus glycoprotein Gn base Gn, Andes virus Gn base domain, ANDV Gn base protein, Andes orthohantavirus Gn base, Hantavirus Gn base glycoprotein, Andes virus envelope glycoprotein Gn base region
Species	Andes Virus
accession number	AF291703.2
Sources	Recombinant Andes Virus Glycoprotein Gn Base (Ala375–Val484) with a C-terminal histidine tag is expressed in CHO cells. The protein is derived from the Andes virus strain Chile-9717869.
Molecular Weight	This protein has a predicted molecular weight of 12–14 kDa (without glycosylation).
Affinity Tag	C-His
Purity	>95% based on SDS-PAGE under reducing condition
Regulatory Status	RUO
Formulation	1xPBS buffer, pH7.4, 0.22 µm filtered
Endotoxin level	Not tested
Protein Concentration	25µg size is bottled at 0.2mg/mL concentration. 100 µg size is supplied at a lot-specific concentration.
Storage and Handling	Briefly centrifuge the vial upon receipt. An unopened vial can be stored at 4°C for up to 2 weeks, or at -20°C or below for up to six months. The protein may be further diluted to 0.1 mg/mL using 0.22 µm-filtered PBS buffer (pH 7.4). For long-term storage, the diluted stock solution should be aliquoted and stored at ≤ –70°C to minimize freeze-thaw cycles. If additional dilution is required, carrier proteins such as FBS or BSA should be added to maintain protein stability.

Background Information

Andes virus (ANDV) is a member of the genus Orthohantavirus within the family Hantaviridae and is one of the primary causative agents of hantavirus cardiopulmonary syndrome (HCPS) in South America. Andes virus is unique among hantaviruses because of its documented ability for person-to-person transmission.
The viral glycoprotein precursor (GPC) is cleaved into the Gn and Gc envelope glycoproteins, which assemble into heteromeric spike complexes on the viral surface. The Gn base domain forms an important structural component of the Gn/Gc spike complex and contributes to stabilization of the prefusion glycoprotein architecture. In addition to its structural role, the Gn base region contains conserved epitopes recognized by broadly neutralizing antibodies and is therefore an important target for antiviral therapeutic and vaccine research. Recombinant Andes Virus Gn Base Protein is useful for structural biology, antibody discovery, epitope mapping, serological assay development, and viral entry studies.

Learn more about Andes Virus in our detailed Infographic.

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