| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 203401 | 25 ug | $30 | ||
| 203402 | 100 ug | $90 |
| Clone | M17/4 |
|---|---|
| Application | Flow Cytometry |
| Reactivity | Mouse |
| Format | Purified |
| Target Name | CD11a, integrin alpha L (ITGAL), Ly-15, Ly-21, LFA-1 α subunit, |
| Isotype | Rat IgG2a |
| Antibody Type | Monoclonal |
| Regulatory Status | RUO |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide |
| Protein Concentration | 0.5 mg/mL |
| Storage&Handling | The antibody solution should be stored between 2°C and 8°C |
| Recommended Usage | For flow cytometric staining, it is recommended to use less than 0.2 ug of this reagent per 0.5-1.0 million cells in a 100 µL volume. Optimal reagent performance should be determined by titration for each specific application. |
| See All Formats | Clone M17/4 |
CD11a, also known as integrin alpha L (ITGAL), is a 180 kDa transmembrane glycoprotein expressed on the surface of all mouse leukocytes. Together with CD18 (integrin β2), CD11a forms the heterodimeric lymphocyte function–associated antigen-1 (LFA-1). LFA-1 plays a central role in leukocyte adhesion and migration through interactions with its ligands ICAM-1, ICAM-2, and ICAM-3. Upon cellular activation, CD11a undergoes a conformational change from a low-affinity to a high-affinity state, enabling firm cell–cell interactions. CD11a is also involved in lymphocyte costimulatory signaling and regulates immune cell activation, trafficking, and effector functions.
Rat IgG2a Isotype Control Antibody
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